What do tacrolimus capsules do?
TACROLIMUS (Prograf(R)) is a medication used to decrease the immune system response. Tacrolimus is used to reduce immune responses and prevent rejection in patients who receive organ or bone marrow transplants. Tacrolimus may be used to treat other conditions such as dermatitis, eczema, or psoriasis.
What should my health care professional know before I take tacrolimus capsules?
They need to know if you have any of these conditions:
• heart disease or heart failure
• high blood pressure
• kidney disease
• an unusual or allergic reaction to tacrolimus, castor oil, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
How should I take this medicine?
Take tacrolimus capsules by mouth. Follow the directions on the prescription label. Swallow the capsules with a drink of water. Take with food or milk or take at bedtime to reduce stomach upset. Do not take with grapefruit juice. Taking tacrolimus with food can decrease the amount absorbed, but if you take every dose in the same way this will be acceptable. Take your doses at regular intervals. Do not take your medicine more often than directed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. Contact your prescriber or health care professional if you miss more than one dose, or if you vomit after a dose.
What other medicines can interact with tacrolimus capsules?
• aluminum hydroxide
• certain medicines for HIV-infection such as protease inhibitors
• grapefruit juice
• medicines for fungal infections
• medicines for seizures
• St. John’s wort
• theophylline or aminophylline
• water pills (diuretics)
Talk to your prescriber or health care professional before taking any of these medicines:
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What side effects may I notice from taking tacrolimus capsules?
Tacrolimus therapy can produce many side effects. These mainly affect the urinary system and the nervous system. Contact your prescriber or health care professional about any unusual effects. Side effects that you should report to your prescriber or health care professional as soon as possible:
• signs of infection – fever or chills, cough, sore throat, pain or difficulty passing urine
• signs of decreased red blood cells – unusual weakness or tiredness, fainting spells, lightheadedness
• blurred vision, increased sensitivity of the eyes to light
• burning or tingling in the hands or feet
• difficulty breathing, wheezing
• frequent urination
• increased thirst or hunger
• ringing in the ears
• skin rash or itching (hives)
• seizures (convulsions)
• stomach, back or general pain
• swelling of the feet or legs, unusual or sudden weight gain
• yellowing of skin or eyes
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• diarrhea or constipation
• difficulty sleeping, nightmares
• dizziness or drowsiness
• hair loss or unusual hair growth
• loss of appetite
• mood changes, depression, confusion
• muscle cramps
• nausea, vomiting
• unusual sensitivity to touch