Imatinib, STI-571 capsules
What do imatinib capsules do?
IMATINIB (Gleevec(TM)) targets specific proteins within distinct cancer cells and stops the cancer cells from growing. Imatinib is used to treat certain cancers including chronic myelogenous leukemia (CML) and specific sarcomas called GISTs. This drug might be used to treat other cancers as well.
What should my health care professional know before I receive imatinib?
They need to know if you have any of these conditions:
infection (especially cold sores or shingles)
heart disease (such as heart failure)
an unusual or allergic reaction to imatinib, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
How should I use this medicine?
Imatinib is taken by mouth. You should take imatinib with food and a full glass of water to decrease the chance of it upsetting your stomach. Follow the directions on the prescription label. Do not take your medicine more often than directed.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
Take your missed dose as soon as you remember. If it is almost time for your next dose, take only that one, and skip your missed dose. Do not take extra or double doses.
What other medicines can interact with imatinib?
There are many possible drug interactions with imatinib. Make sure to tell your health care professional about all the medicines you are taking.
antiviral medicines (such as protease inhibitors, delavirdine, efavirenz, or nevirapine)
certain medicines for fungal infections
certain medicines for high blood pressure
certain medicines for high cholesterol (such as atorvastatin, cerivastatin, lovastatin, simvastatin)
certain pain medicines
ergot medicines (such as Cafergot(R), Migranal(R), D.H.E. 45(R), and others)
medicines for depression
medicines for seizures
St. John’s wort or any herbal products containing St. John’s wort
Talk to your prescriber or health care professional before taking any of these medicines:
Tell your prescriber or health care professional about all other medicines that you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What side effects may I notice from receiving imatinib?
low blood counts – imatinib may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
Side effects that you should report to your prescriber or health care professional as soon as possible:
signs of infection – fever or chills, cough, sore throat, pain or difficulty passing urine
signs of decreased platelets or bleeding – bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine, nosebleeds
signs of decreased red blood cells – unusual weakness or tiredness, fainting spells, lightheadedness
swelling around the eyes or in your legs
sores or white patches in your mouth or throat
sudden weight gain
yellowing of skin or eyes, dark colored urine
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
bone or muscle pain
skin rash, itching